First, a bit of confessional back-story. A while ago, someone from a publisher contacted me by email. Would I be interested in writing something about Craig Venter’s new book, Life at the Speed of Light, around its release? I might, I replied, but only if I could see the book. Very promptly I had my family asking what the express package was that had shown up, which indeed had a copy. That was a number of weeks ago, and I’m still not finished the book (but it is most definitely released; another deadline blown to add to my life tally). It’s not a bad book nor a super long one; it’s just I've had some self-starting issues. When the book arrived, I was deeply immersed in Anathem, and even on Kindle that Neal Stephenson tale is a bit of a doorstop (but a very good one, with its own fun little riff on synthetic biology). Then some crazy crush at work, and at home I’m usually mentally exhausted by homework help (which is another whole topic worth covering, if I ever get the courage). So, end result is that this is not a review of Life at the Speed of Light, but one should eventually happen, if I can figure out the angle I want to attack. Or perhaps I'll just run a bunch of pieces triggered by bits of the book.
I do recommend that it be widely read, with the caveat that one should know in advance it is a highly Venter-centric view of synthetic biology. Since he and the set of talented people he has nucleated around him has been a major contributor to the field, that’s a fair way to tackle things, but it can’t be called a broad overview of the field (at least based on the chapters I have read).
The early chapters are a nice readable summary of how DNA came to be known as the genetic code. There’s a whole rumination possible there on how well Venter treated the subject and how I might do it differently (I love the Hershey-Chase experiment, which is barely covered). There’s also room for some gripes tempered with the realization that writing a whole book is a daunting task. Still, the notes format is infuriating and nearly useless – pages in the book have the chapter names but not numbers on every pair of pages, but the notes are organized into sections by chapter numbers but without names. On an e-reader this wouldn't bother, but in hardcover form it is a nuisance.
But, back to my main topic (which, admittedly, could be seen as one more procrastination strategy with regard to writing an actual review). Venter brings out the idea, which I learned back as a freshman, that biochemists were strongly betting on protein to be the carrier of heredity, with DNA a dark horse or even considered a foolish idea. Only after a series of experiments, culminating with Hershey-Chase, was DNA recognized as clearly the master informational molecule.
Now, there are a bunch of questions to think about here, and I’ve wondered about it since I was an undergraduate. How strong was the case for proteins, and who were the strongest proponents? After some of the key experiments, such as Avery's, who were the holdouts? Were they convinced, or were there holdouts, well into the 1950's and 1960's, unconvinced by the mounting evidence for DNA (and perhaps viewed as cranks).
Nowadays, the idea that DNA is too simple seems ludicrous. But I've been steeped in digital thinking my whole life; I learned about DNA around the same time (around age 8) I learned how to convert decimal to binary and skimmed Gödel, Escher, Bach before I hit junior high. So it seems strange to argue that a language with only four letters couldn't be greatly expressive. But, the 1920s through 1950s were a very different era. Shannon, Turing and others roughing out computer science would have been publishing around then, and probably not in circles that would be widely followed by biochemists. Now, as I suggest in the title, the clear model for a simple language would have been Morse Code, which requires 3 symbols (the pauses between code groups are really a third character after dot and dash). The family had a little telegraph set when I was young (though I never got to learning Morse) and Dad (who grew up in the 20’s and 30’s) built a crystal radio, so it seems likely that at least some biochemists of that time might have been exposed to such a code scheme. This would have also been around the time that most of the periodic table had been filled out and the last key chunk of the underlying basis for the atoms (neutrons) was discovered in the 1930's as well. Did chemists think about the variety that can be created with a 2 letter alphabet of proteins (with neutrons being almost like accent marks) and compare that to the variety of proteins that must be codable?
Talking about this with a colleague today, we came up with some additional questions. We think now in terms of there being twenty canonical amino acids and a bunch of rare ones, but that view of reality has been strongly shaped by knowledge of the genetic code. Natural amino acids are much more varied, though many of the others are rare. What was the history of working out the amino acids in proteins, and when was the set of twenty canonized? Were there amino acids kicked out when they didn’t fit the code, such as hydroxyproline (abundant in collagen, which surely was a source material for early protein biochemistry studies). Did biochemists attempt to create structures like the periodic table to hold the amino acids? Was there any thought that perhaps there remained important amino acids yet to be discovered, much like Technetium filled a long-standing hole in Mendeleev’s creation?
Ideally, I’d have a better idea of these answers, but the fact is that textbooks present the streamlined (“Whig History”) view of things; few if any of the dead ends and side tracks are left in the narrative. Perhaps there are leads in Eighth Day of Creation or even in Kuhn’s The Structure of Scientific Revolutions, but I don’t remember the latter even touching molecular biology (I haven’t read either in about two decades, which isn't really a good thing). If you have any leads on any of this, please feel free to put them in the comments. Perhaps some enterprising student or scholar has already written a treatise covering these grounds; if so I’d love to know of it.