FoG to Roll into Boston Seaport Wednesday & Thursday

The Festival of Genomics, Biodata and AI - thankfully known as FoG and not FogBA or FogBDA - will be at the Boston convention center this Wednesday and Thursday.  It's an interesting conference that typically has two editions each year, one in London and one here in Boston.  I'll be wandering around the floor part of both days - my beacon/hat to be announced on LinkedIn and Twitter that day (leaning hard towards my yellow University of Delaware hat).  FoG works hard to not be your average scientific conference, and I'd like to run down a few things I'm anticipating.   By the way, the world's largest autonomous lab is less than a mile from the conference site and tours are available during the conference - all you need to do is reach out to the tour coordinator to schedule one.  And I'm that, so DM me on LinkedIn and I can set you up.

London Calling: Long-Term R&D

Now to run through the long term technical projections from Oxford Nanopore's Tech Talk.  Well, projection is probably not the correct word - hints and teasers might be closer to the mark.  None of these pronouncements came with any hint of timing for when the community might be able to access them - indeed, CSO Lakmal Jayasinghe made it very clear that this section would have no timing information.  Here is a link to the presentation: what is covered in this piece starts around the 44:40 mark.

London Calling: ONT's Near Term Launches

I returned from London Calling 2026 much as I usually have - exhausted, more than a little hoarse, happy for discussions had and ruing connections missed.  The meeting felt much like prior ones, except in all the ways it was a little different.  The company continues its trajectory towards restraint and corporate maturity, with new CEO Francis Van Parys for the first time exhibiting his "evolution not revolution" messaging for the company's direction.  ONT's technical presentation was divided into two parts: near term that came with release dates = none of them even as distant as the end of the summer - and long term which had no hint of timing.  This piece will focus on the near term advancements and a separate one will cover the long term updates.  The entire presentation is already available on YouTube.

London Calling 2026 Preview

My series on Craig Venter is on a small pause since I didn't get it out before I arrived here in London for Oxford Nanopore's annual shindig at Old Billingsgate.  On the plus side (well, I hope my readers find it a plus), I've sketched out an additional piece - I realized that our world of fast whole genome sequencing powered by long read technologies such as Oxford Nanopore may make it challenging for many to remember the genomics world of the 1990s and how there were great differences in opinion on how to go about sequencing genomes.  But back to London Calling - this is an interesting moment in the history of the company and it shows in the program. So without more ado, here are some key topics and questions on my mind.

Personal Reflections on Craig Venter: Expressed Sequence Tags

Venter's big Expressed Sequence Tag - soon known as ESTs -  paper came out in June during my final summer as an intern; I photocopied it at my internship. I looked it up, and it had only a bit over 600 sequences - a small beginning to what would become an industry-wide exercise.  That was a momentous time for me, as only the past December had I pivoted from thinking I would get a degree in experimental plant molecular biology to focusing on computational genomics. Venter was not the first person to feed an RNA library into a DNA sequencing workflow without prior screening; I believe Gregor Sutcliffe holds that milestone.  But Venter did it on a much larger scale and with much more flash.  He pitched it as a way to skim the cream of the human genome when the official Human Genome Project was just getting going.  And as would characterize much of his career, it is the response of others in the community that was as much his contribution as his own work.

Personal Reflections on Craig Venter: Preface

Craig Venter's sudden passing has triggered many writings about his life and work.  I'm overdue on my own personal reflections, and am breaking them into three thematic pieces. While I only met him a few times and never one-on-one, his career had an enormous impact on mine. So I am going to write a series of posts this week reviewing, in a very personal way, Venter's enormous impact on genomics and synthetic biology. I'm sure I won't do it proper justice, and I won't be surprised if my memory plays tricks on me - please do point out any egregious errors of fact and feel free to contest my opinions if you feel they are unfounded.

If My Agent Can't See Your Catalog, Will It Exist Much Longer?

Another edition of my dabbling with AI.  Somewhat like what I reported before - a customer asked if Ginkgo Cloud Lab's Echo-MS option could configure an assay to replicate the analytical results in a published paper, so I'm using Claude to do the heavy lifting.  Plus part of what I described earlier showed some issues on review.  But the big thing I'm keying into this morning is Claude is having difficulty with accessing a major chemical catalog I pointed it at - and I wonder how long that situation will be tenable.  Maybe not for a big company, but how many small companies will have an existential crisis when it turns out AI co-scientists and full agentic scientists have been silently passing them by?