Omics! Omics!

A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery

Tuesday, March 18, 2025

Mission Impossible: Methylomics

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Good morning Mr. Hunt. Today's briefing will have a bit more background than usual - you haven't tangled with biotechnology since th...
2 comments:
Saturday, February 22, 2025

Is Midi Read Sequencing A Thing?

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Throughout the two pieces on Roche SBX sequencing I sprinkled the term “midi read sequencing”.  Here I’m going to explore in more detail thi...
5 comments:
Thursday, February 20, 2025

Roche Ripple Predictions

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In the prior piece , I covered the technical details unveiled by Roche for their SBX technology, but generally tried to avoid predicting its...
9 comments:

Roche Xpounds on New Sequencing Technology

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Bar bets can be a powerful force in human society.  One of the best known books on the planet, The Guinness Book of World Records, originate...
14 comments:
Monday, January 27, 2025

Olink Reveal: Focused Proteomics, Simplified

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I’ve covered a lot of genomics in this space, but there is an inherent challenge to studying biology via DNA - DNA is the underlying bluepri...
Wednesday, January 22, 2025

Illumina & NVIDIA Team to Remake How to Train Your DRAGEN

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If you've been in a movie theater recently, you may have seen a trailer for a mixed live action and animation spectacle called How To Tr...
Wednesday, November 06, 2024

Benchtop HiFi: PacBio Unveils Vega

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Well, the embargo has passed and one of the worst kept rumors of genomics land has come true: at this year's ASHG PacBio has unveiled th...
3 comments:

Revio Refresh

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ASHG is ongoing and tonight PacBio has a big party planned, with an unnamed musical guest.  Rumors swirl as to what will be announced at tha...
Wednesday, October 09, 2024

MiSeq Makeover

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MiSeq is the the oldest instrument in Illumina's lineup, first unveiled back in 2011 .  MiSeq's launch stole much of the thunder fro...
4 comments:
Friday, September 27, 2024

QuantumScale: Two Million Cells is the Opening Offer

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I'm always excited by sequencing technology going bigger.  Every time the technology can generate significantly more data, experiments t...
Thursday, August 29, 2024

Illumina Would Like to Change the Conversation

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A maxim from the great but fictional advertising executive Don Draper: "if you don't like what people are saying, change the conver...
4 comments:
Monday, July 29, 2024

Musings on Possible Fixes To PacBio & ONT's Achilles Heels

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I recently tried to place a claim that I had first conceived Oxford Nanopore's "6b4" strategy for solving homopolymers, but th...
1 comment:
Tuesday, July 09, 2024

Tagify: seqWell's Line of Tagmentation Reagents Awaits Your Creative Thoughts!

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One of the most important enzymes in the sequencing world, one which enables spectacular creativity on the part of novel assay designers, is...
Friday, June 28, 2024

mRNA Therapeutic / Vaccine Quality Control: A Major ONT Opportunity?

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Oxford Nanopore is in the process of morphing into a product-focused company, and so must identify specific markets in which they believe na...
Thursday, June 27, 2024

ONT T2T Genome Bundle: Hot New Thing or Flash in Pan?

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Last month at London Calling, Oxford Nanopore announced a consumables and reagent bundle which enables generating six telomere-to-telomere (...
2 comments:
Wednesday, June 26, 2024

ScalePlex: Easing High Sample Count 3’ scRNA Sequencing

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Scale Bioscience o fficially rolled out today - their rep was already talking about it at the Boston Single Cell Symposium I attended yester...
Monday, June 24, 2024

Aftermath

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I have multiple drafts of posts trying to finish up my London Calling items and then a long list of ideas in various stages of gestation - a...
Friday, June 07, 2024

CariGenetics: Breakthrough Breast Cancer Genetics in the Caribbean - but Also a Template for ONT Clinical Push?

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London Calling isn't nearly as exhausting as AGBT, but the first day of talks is packed and then follows with the social event that goes...
1 comment:
Tuesday, June 04, 2024

ElysION vs. TraxION: Divergent Shots at Applied Market End-To-End Automation

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London Calling was a particularly good opportunity to take stock of Oxford Nanopore's progress to a "fire-and-forget" sample-t...
4 comments:
Tuesday, May 21, 2024

Thoughts on A Decade of Oxford Nanopore Sequencing

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I'm writing this the eve of Oxford Nanopore's London Calling conference.  This is a big one, as this summer marks the 10th anniversa...
5 comments:
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About Me

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Keith Robison
Dr. Robison spent 10 years at Millennium Pharmaceuticals working with various genomics & proteomics technologies & working on multiple teams attempting to apply these throughout the drug discovery process. He spent 2 years at Codon Devices working on a variety of protein & metabolic engineering projects as well as monitoring a high-throughput gene synthesis facility. After a brief bit of consulting, he rejoined the cancer drug discovery field at Infinity Pharmaceuticals in May 2009. In September 2011 he joined Warp Drive Bio, a startup applying genomics to natural product drug discovery. In February 2019 he joined Ginkgo Bioworks, a synthetic biology company. Other recurring characters in this blog are his late loyal Shih Tzu Amanda, his current Shih Poo Lily and his now adult son alias TNG (The Next Generation). Dr. Robison can be reached via his Gmail account, keith.e.robison@gmail.com You can also follow him on Twitter as @OmicsOmicsBlog.
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