Omics! Omics!

A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery

Friday, June 28, 2024

mRNA Therapeutic / Vaccine Quality Control: A Major ONT Opportunity?

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Oxford Nanopore is in the process of morphing into a product-focused company, and so must identify specific markets in which they believe na...
Thursday, June 27, 2024

ONT T2T Genome Bundle: Hot New Thing or Flash in Pan?

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Last month at London Calling, Oxford Nanopore announced a consumables and reagent bundle which enables generating six telomere-to-telomere (...
2 comments:
Wednesday, June 26, 2024

ScalePlex: Easing High Sample Count 3’ scRNA Sequencing

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Scale Bioscience o fficially rolled out today - their rep was already talking about it at the Boston Single Cell Symposium I attended yester...
Monday, June 24, 2024

Aftermath

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I have multiple drafts of posts trying to finish up my London Calling items and then a long list of ideas in various stages of gestation - a...
Friday, June 07, 2024

CariGenetics: Breakthrough Breast Cancer Genetics in the Caribbean - but Also a Template for ONT Clinical Push?

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London Calling isn't nearly as exhausting as AGBT, but the first day of talks is packed and then follows with the social event that goes...
1 comment:
Tuesday, June 04, 2024

ElysION vs. TraxION: Divergent Shots at Applied Market End-To-End Automation

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London Calling was a particularly good opportunity to take stock of Oxford Nanopore's progress to a "fire-and-forget" sample-t...
4 comments:
Tuesday, May 21, 2024

Thoughts on A Decade of Oxford Nanopore Sequencing

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I'm writing this the eve of Oxford Nanopore's London Calling conference.  This is a big one, as this summer marks the 10th anniversa...
5 comments:
Monday, May 20, 2024

FOMO Index at All Time High This Week

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I'm in the airport getting set to jet off to  London Calling  - already spotted a kindred spirit at Logan doing the same, but I could be...
1 comment:
Friday, May 17, 2024

HiFi WGS As A (Nearly) Unified Tool For Rare Genetic Disease Diagnosis

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What is now way back in February, Alexander Hoischen presented a talk at AGBT which described early results from an effort to apply PacBio H...
1 comment:
Sunday, May 12, 2024

DoveTail Transposes Their Hi-C Methodology

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Technologies vying for state-of-the-art in human genome analysis are a recurrent theme in this space, and there are many ideas on this in th...
2 comments:
Friday, May 10, 2024

AQTUAL: Arthritis Drug Selection Via Assaying Cell Free Chromatin

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[Note: after I initially released this, Dr. Abdueva spotted some glitches; I pulled it back for editing & then got swept into London Cal...
Tuesday, May 07, 2024

On The Expanding Versatility of Single Molecule Sequencing for Detecting Anomalous DNA

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An exciting aspect of true single molecule sequencing has been the detection of methylated bases.  Both Oxford Nanopore and Pacific Bioscien...
1 comment:
Wednesday, May 01, 2024

First Illumina Complete Long Reads Preprint

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Readers of this space might have detected a significant slant towards skepticism in my coverage of Illumina Complete Long Reads (iCLR), exac...
4 comments:
Tuesday, April 30, 2024

A Peek At QuantumSI's Protein Sequencer

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A number of academic labs and startups have been trying to build new ways of parallel sequencing of large numbers of peptides using schemes ...
1 comment:
Tuesday, April 23, 2024

Bruker Wins NanoString Auction

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NanoString declaring bankruptcy on the eve of 2024's edition of AGBT was a shock to many at the meeting and then there was confusion: wo...
3 comments:
Wednesday, April 17, 2024

PacBio Plummets

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PacBio announced preliminary earnings yesterday, and the nearly immediate result was a 50% plunge in their share price.  Along with the ea...
15 comments:
Wednesday, April 10, 2024

Thoughts on RNU4-2 Mutation Paper

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A new preprint based on Genomics UK data has identified a set of single base insertion mutations (predominantly a specific A insertion)  in...
Thursday, March 28, 2024

Post-AGBT: VizGen & Scale Biosciences Partner

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It's been just a few weeks since I sat poolside at AGBT with VizGen CEO Terry Lo and Scale Biosciences CEO Giovanna Prout to discuss the...
Monday, March 11, 2024

BioNano In Peril Again

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While I still have a pair of pre-AGBT and AGBT interviews to write up - plus a long list of post ideas inspired by AGBT - breaking news abou...
Thursday, February 29, 2024

Post-AGBT: Sequencing Hardware Roundup

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Some updates on the sequencing instrument vendors, save Ultima Genomics and Element Biosciences which I've covered already.
2 comments:
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Keith Robison
Dr. Robison spent 10 years at Millennium Pharmaceuticals working with various genomics & proteomics technologies & working on multiple teams attempting to apply these throughout the drug discovery process. He spent 2 years at Codon Devices working on a variety of protein & metabolic engineering projects as well as monitoring a high-throughput gene synthesis facility. After a brief bit of consulting, he rejoined the cancer drug discovery field at Infinity Pharmaceuticals in May 2009. In September 2011 he joined Warp Drive Bio, a startup applying genomics to natural product drug discovery. In February 2019 he joined Ginkgo Bioworks, a synthetic biology company. Other recurring characters in this blog are his late loyal Shih Tzu Amanda, his current Shih Poo Lily and his now adult son alias TNG (The Next Generation). Dr. Robison can be reached via his Gmail account, keith.e.robison@gmail.com You can also follow him on Twitter as @OmicsOmicsBlog.
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