Omics! Omics!

A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery

Thursday, May 30, 2019

The Genius of Plongle

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I noted in my roundup of Oxford Nanopore technical announcements that I loved the Plongle concept.  This is really both a new application-sp...
1 comment:

ONT's Horrid Data Storage Folly

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In the coverage of ONT's announcements at London Calling , I specifically left out one of Clive's Skunk Works projects.  This would ...
3 comments:
Wednesday, May 29, 2019

ONT's London Calling Announcements, Pass One

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The annual big Clive Brown London Calling talk had a twist this year  Brown introduced a set of senior lieutenants at Oxford Nanopore and th...
Thursday, May 23, 2019

Nanopore's Long DNA Paradox

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The first half day of London Calling has already delivered the usual mix of scientific excitement.  The prospect of lives, particularly thos...
2 comments:
Tuesday, May 21, 2019

Care to Pore Over My Laundry List?

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London Calling is this week, so get ready for lots of Oxford Nanopore in my Twitter channel and if I'm on the ball, in this space.  ONT ...
Monday, May 20, 2019

Mass Recoded E.coli Genome Not Tripped Up By Programmed Frameshifts

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There's a paper this week in Nature announcing an E.coli genome which has had two serine codons ( UCA , UCG ) and one stop codon ( UAG...
Friday, May 17, 2019

My Career's Double Slit Experiment (or, A Funny Thing Happened on the Way to the Drydock)

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When I announced recently that I had moved over to Ginkgo Bioworks, I was compelled to leave out an important part of that story.  Indeed, ...
Monday, May 06, 2019

Genapsys' Base Caller: Mysterious, But Not Ideal?

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When I wrote about Genapsys' pre-print on their sequencing system the other night, I intended that to be the last I wrote until some ma...
1 comment:
Thursday, May 02, 2019

Poking at Genapsys Preprint

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Genapsys is continuing down the path of pre-launch information, most recently releasing a pre-print .  I'm looking at this pre-print cri...
Wednesday, April 24, 2019

Want to Run An Exciting Sequencing Group? Ginkgo Is Looking for You!

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I've awakened from my blogging torpor to point out a really interesting career opportunity for the types who might read this space. Gin...
Monday, March 25, 2019

Nanosens Publishes Proof-of-Concept for Point-of-Care CNV Diagnostic

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Here's a killer technological challenge for anyone: design a scheme to detect vanishingly small concentrations of a valuable analyte in ...
3 comments:
Wednesday, February 20, 2019

Beyond Generations: My Vocabulary for Sequencing Tech

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Many writers have attempted to divide Next Generation Sequencing into Second Generation Sequencing and Third Generation Sequencing.  Persona...
5 comments:
Thursday, February 07, 2019

Failing to Fetch An Interesting Result on Dog Oncogene Homologs

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An idea for a little exploration occurred to me back at Infinity -- that is 7.5 years ago -- that I've never tried out.  But I never got...
Wednesday, January 30, 2019

Covaris Grabs A Spot on the Liquid Handler Deck

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For as long as I can remember, Covaris has been the standard in DNA shearing for high throughput short read sequencing.  Their benchtop unit...
3 comments:
Tuesday, January 29, 2019

Patent Dive: Genapsys

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Here's a dangerous statement for me: I actually enjoyed reading some patents recently.  Now, before you get any ideas in your head about...
Monday, January 28, 2019

Metabolic Whac-a-Mole

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Derek Lowe summarized a really cool paper back in October .  I've been meaning to grab a copy, but discovered recently that the MIT libr...
Friday, January 25, 2019

2019 Tech Speculations: Oxford Nanopore

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As promised in the last post, I'm segregating out Oxford Nanopore.  Admittedly I tend to cover them relatively closely -- though I never...
Tuesday, January 15, 2019

2019 Sequencing Tech Speculations: Will We Actually See New Entrants?

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An astute reader caught a sentence fragment about MGI in last night's Illumina JPM roundup -- the unfortunate evidence of a a mental ba...
4 comments:
Monday, January 14, 2019

Illumina JPM Talk

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Illumina CEO Francis deSouza delivered his J.P. Morgan Healthcare Conference talk ( webcast audio , slides & Q&A audio ) a week ago...
5 comments:
Sunday, January 06, 2019

2019 Sequencing Tech Speculations, Part I: Illumina & MGI

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Next week is the J.P. Morgan Healthcare Conference.  It's striking this year the paucity of companies in the genomics space -- Illumina ...
3 comments:
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Keith Robison
Dr. Robison spent 10 years at Millennium Pharmaceuticals working with various genomics & proteomics technologies & working on multiple teams attempting to apply these throughout the drug discovery process. He spent 2 years at Codon Devices working on a variety of protein & metabolic engineering projects as well as monitoring a high-throughput gene synthesis facility. After a brief bit of consulting, he rejoined the cancer drug discovery field at Infinity Pharmaceuticals in May 2009. In September 2011 he joined Warp Drive Bio, a startup applying genomics to natural product drug discovery. In February 2019 he joined Ginkgo Bioworks, a synthetic biology company. Other recurring characters in this blog are his late loyal Shih Tzu Amanda, his current Shih Poo Lily and his now adult son alias TNG (The Next Generation). Dr. Robison can be reached via his Gmail account, keith.e.robison@gmail.com You can also follow him on Twitter as @OmicsOmicsBlog.
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