Omics! Omics!

A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery

Wednesday, February 20, 2019

Beyond Generations: My Vocabulary for Sequencing Tech

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Many writers have attempted to divide Next Generation Sequencing into Second Generation Sequencing and Third Generation Sequencing.  Persona...
5 comments:
Thursday, February 07, 2019

Failing to Fetch An Interesting Result on Dog Oncogene Homologs

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An idea for a little exploration occurred to me back at Infinity -- that is 7.5 years ago -- that I've never tried out.  But I never got...
Wednesday, January 30, 2019

Covaris Grabs A Spot on the Liquid Handler Deck

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For as long as I can remember, Covaris has been the standard in DNA shearing for high throughput short read sequencing.  Their benchtop unit...
3 comments:
Tuesday, January 29, 2019

Patent Dive: Genapsys

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Here's a dangerous statement for me: I actually enjoyed reading some patents recently.  Now, before you get any ideas in your head about...
Monday, January 28, 2019

Metabolic Whac-a-Mole

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Derek Lowe summarized a really cool paper back in October .  I've been meaning to grab a copy, but discovered recently that the MIT libr...
Friday, January 25, 2019

2019 Tech Speculations: Oxford Nanopore

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As promised in the last post, I'm segregating out Oxford Nanopore.  Admittedly I tend to cover them relatively closely -- though I never...
Tuesday, January 15, 2019

2019 Sequencing Tech Speculations: Will We Actually See New Entrants?

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An astute reader caught a sentence fragment about MGI in last night's Illumina JPM roundup -- the unfortunate evidence of a a mental ba...
4 comments:
Monday, January 14, 2019

Illumina JPM Talk

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Illumina CEO Francis deSouza delivered his J.P. Morgan Healthcare Conference talk ( webcast audio , slides & Q&A audio ) a week ago...
5 comments:
Sunday, January 06, 2019

2019 Sequencing Tech Speculations, Part I: Illumina & MGI

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Next week is the J.P. Morgan Healthcare Conference.  It's striking this year the paucity of companies in the genomics space -- Illumina ...
3 comments:
Thursday, January 03, 2019

2019 Resolutions

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2019 is upon us; I'm hoping it will be a bit less eventful than 2018.  It wasn't all bad -- I took two trips that delivered scenery ...
1 comment:
Thursday, December 13, 2018

An Unfortunate Master Class in Poor Plotting

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I hope my admiration for Pacific Biosciences intellectual acumen was clear in my post on the acquisition by Illumina , because now I'm g...
2 comments:
Wednesday, December 12, 2018

Flappie vs. Albacore via Counterr

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I'm going to go through some analysis of Oxford Nanopore basecalling, running some quick comparisons using a freely-available tool calle...
1 comment:
Thursday, November 29, 2018

Nanopore Community Meeting 2018: The Clive Report

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Given it's late and I just dashed through a classic San Francisco downpour, I'm going to mostly stick to covering Clive Brown's ...
3 comments:
Wednesday, November 28, 2018

A Few Things Before Nanopore Community Meeting Begins

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Nanopore Community Meeting begins within the hour.  San Francisco is spectacular as ever -- Alcatraz Island disappearing into the fog as I f...
Tuesday, November 27, 2018

Nanopore Community Meeting 2018 Preview

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Okay, now that I'm done venting -- for now -- about ONT's customer service experience   (well, almost done -- they sent me the same ...

How Not Do Think Like A Customer: Examples from ONT and AMZN

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I'd planned today to use some downtime to write up a preview of the Nanopore Community Meeting which I am attending tomorrow and Thursda...
2 comments:
Thursday, November 15, 2018

Failure: The Real Secret Sauce of Engineering

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I took one swing at Vijay Pande's overly rosy piece on applying engineering methods to biology and medicine  and similar minded efforts...
4 comments:
Thursday, November 08, 2018

No, the Groves Fallacy Can't be Retired Yet

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Vijay Pande has a thought-provoking piece in Scientific American on the Groves Fallacy , though in the end I'm afraid mostly what he pro...
Monday, November 05, 2018

Illumina Buys PacBio: More Thoughts

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Illumina surprised pretty much everyone in the genomics community by announcing the purchase of Pacific Biosciences.  I had spent Thursday d...
5 comments:
Tuesday, October 16, 2018

You Can Be Impatient Running MInIONs, But Not Feeding Them

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Yes, it's been way too long since I wrote here.  Even longer since I did so with any regularity.  There was always some list of things d...
1 comment:
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Keith Robison
Dr. Robison spent 10 years at Millennium Pharmaceuticals working with various genomics & proteomics technologies & working on multiple teams attempting to apply these throughout the drug discovery process. He spent 2 years at Codon Devices working on a variety of protein & metabolic engineering projects as well as monitoring a high-throughput gene synthesis facility. After a brief bit of consulting, he rejoined the cancer drug discovery field at Infinity Pharmaceuticals in May 2009. In September 2011 he joined Warp Drive Bio, a startup applying genomics to natural product drug discovery. In February 2019 he joined Ginkgo Bioworks, a synthetic biology company. Other recurring characters in this blog are his late loyal Shih Tzu Amanda, his current Shih Poo Lily and his now adult son alias TNG (The Next Generation). Dr. Robison can be reached via his Gmail account, keith.e.robison@gmail.com You can also follow him on Twitter as @OmicsOmicsBlog.
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