Omics! Omics!

A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery

Friday, July 21, 2017

A Third GridION X5 Pricing Plan

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When Oxford Nanopore announced their GridION X5 instrument in March , I and others attempted to parse the difference between the two pricing...
5 comments:
Wednesday, June 28, 2017

STAT Proves Not Resistant To Antibiotic Tropes

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Tuesday's Boston Globe carried a piece originating from STAT news on an interesting natural product antibiotic, pleuromutilin.  A resea...
Wednesday, June 14, 2017

New Life in the Sanger Market

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In my bit on " I'm not dead yet" technologies recently, I included large scale Sanger sequencing. That reflects to a large de...
6 comments:
Tuesday, June 06, 2017

Ice Ghosts:A Shortage of Maps

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I'm going to step outside the usual topic space here and cover an interesting but frustrating book I read partly on the flight to London...
3 comments:
Monday, May 22, 2017

What Is (and Is Not) Sequence Assembly?

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In the closing talk of the pre-London Calling workshop, Hans Jansen had closed his presentation with a question whether at some future date ...
1 comment:
Thursday, May 18, 2017

London Calling 2017: Plant & Animal de novo Genomes

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Okay, I'm desperately behind on writing up the external science from London Calling.  Not helpful that I claimed I would not only do so,...
Sunday, May 14, 2017

SFAF & I'm Not Dead Yet Technologies

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Jonathan Jacobs posted his annual reminder that the Sequencing, Finishing and Analysis in the Future Meeting (SFAF) will be this week.  Alas...
1 comment:
Tuesday, May 09, 2017

London Calling 2017: A Theme of Consolidation

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London Calling 2017 came to a close last Friday.  Any excuses of jet lag or nights running up ONT's bar tab won't hold up much longe...
10 comments:
Thursday, May 04, 2017

Nanopore Workshop Notes

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I attended on Wednesday the London Calling pre-conference workshop, an add-on for those wishing for help getting started with MinION sequenc...
4 comments:
Tuesday, May 02, 2017

London Calling 2017: A Preview

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Oxford Nanopore's London Calling confab runs Thursday and Friday, with a training workshop on Wednesday.  I'll be there -- who can r...
2 comments:
Monday, May 01, 2017

Oxford Nanopore's Enigmatic Patent Litigation

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Oxford Nanopore has launched lawsuits in the UK and Germany against Pacific Biosciences, alleging infringement of a European patent license...
5 comments:
Wednesday, April 26, 2017

Exercise: A Sequence Signature for Transcription-Translation Coupling in Bacteria?

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A pretty common question over on Quora is something along the lines of "how do I learn bioinformatics".  Great question!  Tonight ...
Saturday, April 22, 2017

Pinniped Karyotypes & N50 Statistics

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In my recent piece on long read assembly , I laid out part of the case against the N50 statistic.  Historically, the issues with the statist...
Thursday, April 20, 2017

Time to Retire HeLa?

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A TV movie produced by and starring American culture mogul Oprah Winfrey is about to hit screens which dramatizes Rebecca Skloot's The I...
2 comments:
Thursday, April 13, 2017

Alexandria Jumps Into Shuttle Business

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A restaurant I frequented during my grad school days had a map on the wall showing Boston area transit routes from roughly the 1940s.  Remar...
Monday, April 10, 2017

10x Launches Mass T-Cell Receptor Decoding

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Adaptive immunity is an endlessly fascinating topic which I have not explored very deeply, which is particularly unfortunate given the many ...
Tuesday, April 04, 2017

SageHLS: Automated uHMW DNA Preparation

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Advances in optical mapping, linked reads, PacBio and nanopore sequencing are enabling generating highly contiguous large genome sequences ...
Thursday, March 30, 2017

Chromosome-Scale Scaffolds And The State of Genome Assembly

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A new paper on using Hi-C sequencing appeared in Science recently, demonstrating the generation of chromosome-length scaffolds for human as ...
2 comments:
Monday, March 27, 2017

Differential Mammalian Toxicity: Why Do Some Human Foods Kill Dogs?

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I've been contemplating this post for a while, but it can be seen as another angle on my recent post on the challenges of drug discovery...
3 comments:
Saturday, March 25, 2017

Targets: Drugability Revisited

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My correspondent @datarade shot a tweet my way on his quest to understand drug discovery. He does this despite the fact I've promised po...
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About Me

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Keith Robison
Dr. Robison spent 10 years at Millennium Pharmaceuticals working with various genomics & proteomics technologies & working on multiple teams attempting to apply these throughout the drug discovery process. He spent 2 years at Codon Devices working on a variety of protein & metabolic engineering projects as well as monitoring a high-throughput gene synthesis facility. After a brief bit of consulting, he rejoined the cancer drug discovery field at Infinity Pharmaceuticals in May 2009. In September 2011 he joined Warp Drive Bio, a startup applying genomics to natural product drug discovery. In February 2019 he joined Ginkgo Bioworks, a synthetic biology company. Other recurring characters in this blog are his late loyal Shih Tzu Amanda, his current Shih Poo Lily and his now adult son alias TNG (The Next Generation). Dr. Robison can be reached via his Gmail account, keith.e.robison@gmail.com You can also follow him on Twitter as @OmicsOmicsBlog.
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