Omics! Omics!

A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery

Thursday, March 30, 2017

Chromosome-Scale Scaffolds And The State of Genome Assembly

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A new paper on using Hi-C sequencing appeared in Science recently, demonstrating the generation of chromosome-length scaffolds for human as ...
2 comments:
Monday, March 27, 2017

Differential Mammalian Toxicity: Why Do Some Human Foods Kill Dogs?

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I've been contemplating this post for a while, but it can be seen as another angle on my recent post on the challenges of drug discovery...
3 comments:
Saturday, March 25, 2017

Targets: Drugability Revisited

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My correspondent @datarade shot a tweet my way on his quest to understand drug discovery. He does this despite the fact I've promised po...
Tuesday, March 21, 2017

Obviousness: Rarely Obvious

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Pacific Biosciences has made new thrusts in their ongoing intellectual property action against Oxford Nanopore, adding two recently issued ...
17 comments:
Monday, March 20, 2017

plexWell: Illumina Libraries by the Plateload

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The advent of so-called next generation sequencers, particularly those from Illumina, have brought the price of sequence data down dramatica...
3 comments:
Tuesday, March 14, 2017

ONT Updates: GridION X5, PromethION, 1D^2, Scrappie, FPGAs and More

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Clive Brown gave a webcast today with updates on a number of Oxford Nanopore topics, but clearly the flagship announcement was a new instrum...
32 comments:
Wednesday, March 08, 2017

MinION Leviathan Reads: An Update

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Last week I posted a piece  on some amazing new nanopore data, only to be red-faced to discover the next morning that I had misread the a...
8 comments:
Thursday, March 02, 2017

Catching Up On Oxford Nanopore News: More, Better, Meth & Huge

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Oxford Nanopore and its collaborators have shown at least three interesting advances in the last few months which I haven't yet covered;...
14 comments:
Tuesday, February 28, 2017

Earth BioGenome Project: Ill-Conceived Megaproject Du Jour

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There's been a bit of buzz recently about an unfunded proposal to ultimately sequence every living species on Earth, warming up by seque...
8 comments:
Friday, February 17, 2017

#AGBT17 Tweet Archive is Up!

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I've used my scheme for collecting and organizing tweets to capture most of the feed from this week's AGBT17 conference.  I still ne...
2 comments:
Monday, February 13, 2017

Bagging Novel Enzymes Via Mass Spec Metabolomics

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Obtaining a complete genome sequence for a bacterium or archean is essentially a solved problem, if you can culture the bug.  Grow up biomas...
Thursday, February 02, 2017

Could Hermione Tackle MinION Yield Variability?

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A bit of a foray into Oxford Nanopore land again.  By replacing a bench bumbler with someone competent, we've seen some success with o...
2 comments:
Wednesday, February 01, 2017

Illumina Drops NeoPrep

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At the 2015 AGBT meeting, Illumina launched the NeoPrep , a ~$40K instrument to automate the preparation of up to 16 sequencing libraries at...
2 comments:
Tuesday, January 31, 2017

On The International Nature of American Biotech

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I'll spend two hours in project meetings tomorrow. Around the table will be a group of scientists who are all at the top of the game and...
5 comments:
Friday, January 27, 2017

Perl: The Bad Habit I Can't Quite Kick

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TULIP is a new assembler for long, error-rich reads such as from nanopore. I was a bit stunned to see that TULIP is written in Perl; I was ...
6 comments:
Tuesday, January 24, 2017

Notes on a Conversation with 10X

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I've been remiss in writing up a piece on 10X Genomics based on a phone discussion last week with Michael Schnall-Levin (VP Computationa...
Saturday, January 21, 2017

Gen9 Vanishes

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Earlier this week one of my colleagues had gotten a somewhat ominous email  from the CEO of Gen9 titled "Special Gen9 Announcement...
7 comments:
Tuesday, January 17, 2017

Bio-Rad Sips Up RainDance

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Monday evening brought news that Bio-Rad has further consolidated its grip on the droplet microfluidics space by acquiring RainDance Technol...
Monday, January 09, 2017

Illumina Unveils HiSeq Successor NovaSeq

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At today's J.P. Morgan Healthcare Conference Illumina made a number of small announcements -- some new partnerships, Firefly on track fo...
9 comments:
Sunday, January 08, 2017

Pondering What Is Lost In Teaching Translation

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I'm good at acquiring distractions, and a relatively new one is Quora.  This site allows users to ask questions which are then answered ...
1 comment:
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About Me

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Keith Robison
Dr. Robison spent 10 years at Millennium Pharmaceuticals working with various genomics & proteomics technologies & working on multiple teams attempting to apply these throughout the drug discovery process. He spent 2 years at Codon Devices working on a variety of protein & metabolic engineering projects as well as monitoring a high-throughput gene synthesis facility. After a brief bit of consulting, he rejoined the cancer drug discovery field at Infinity Pharmaceuticals in May 2009. In September 2011 he joined Warp Drive Bio, a startup applying genomics to natural product drug discovery. In February 2019 he joined Ginkgo Bioworks, a synthetic biology company. Other recurring characters in this blog are his late loyal Shih Tzu Amanda, his current Shih Poo Lily and his now adult son alias TNG (The Next Generation). Dr. Robison can be reached via his Gmail account, keith.e.robison@gmail.com You can also follow him on Twitter as @OmicsOmicsBlog.
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