Omics! Omics!

A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery

Thursday, December 31, 2015

Closing the books on 2015

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The last line of Perl has been written, the last SQL select executed. As 2015 draws to a close, I want to extend a thank you to everyone who...

Loose 2015 Threads #2: Thanks for the help with bootstrap values

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I owe a belated thank you to everyone who responded to my post on my muddled thinking around phylogenetic tree bootstrap values .  I think I...
Wednesday, December 30, 2015

Loose 2015 threads #1: MiSeq 2x300 Issues

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Before 2015 ends, I'd like to tie up two loose threads.  In doing so, I'll deviate slightly from my usual pattern and publish two p...
2 comments:
Monday, December 28, 2015

Thoughts on the Synthetic Biology of Seveneves

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Neal Stephenson's Seveneves is a sprawling space novel of truly epic ambition and scope, which I enjoyed thoroughly.  I'm not going...
Friday, December 11, 2015

MinION and Time-to-Result

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Peripatetic blogger Dale Yuzuki posed a question on my last piece which I'll answer with a separate post because it crystallizes for m...
1 comment:
Monday, December 07, 2015

MinION Community Meeting 2015: Reflections & Wrap-Up

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I spent the end of last week at the New York Genome Center for Oxford Nanopore's MinION Community Meeting 2015.  Since the family joined...
5 comments:
Monday, November 30, 2015

Admitting to Ignorance on Interpreting Bootstrap Values

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Okay, one of the points of this space has always been to crowdsource the project of educating myself, which also means on of the underlying ...
3 comments:
Tuesday, November 24, 2015

Well, that was brief!

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BGI news today  is that they are jettisoning the Revolocity large sequencing system , announced all the way back in June.  Along with the p...
4 comments:
Monday, November 16, 2015

Do Demons Dream of Phylogeny Packages?

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Miserable day today  - spent my entire day wrestling with bad formats and flaky tools and trying to bull my way past them, leading to many a...
5 comments:
Wednesday, November 04, 2015

Comments on "The use and misuse of supplementary material in science publications"

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Mihai Pop and Steven Salzberg have a n opinion piece in BMC Bioinformatics titled "Use and mis-use of supplementary material in science...
5 comments:
Saturday, October 31, 2015

HelicosTech Back on the Dance Floor?

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It's Halloween, and as i s my habit I fired up  Saint-SaĆ«ns , As death tunes up his violin in a graveyard, the dead residents live again...
3 comments:
Tuesday, October 27, 2015

BGI Launches the BGISEQ-500

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This weekend brought the formal launch of the BGISEQ-500 desktop sequencing instrument from BGI (though deliveries won't begin until ea...
1 comment:
Wednesday, October 21, 2015

Concepts for Better Sequencer Calibration

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Last week's release of the MARC data for the Oxford Nanopore MinION rebooted a train of thought I've had around DNA samples used as...
2 comments:
Tuesday, October 20, 2015

Dovetail Takes Flight

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Back in March I covered the unveiling of Dovetail Genomics' approach to scaffolding genomes  via deriving long distance constraints fro...
Monday, October 19, 2015

MARC spots the Ox(ford)

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Last week's end brought the initial report from MARC , the MinION Analysis and Reference Consortium, detailing a body of experiments int...
Thursday, October 01, 2015

PacBio Sequel: Smaller Box, Bigger Bang

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Boy, am I regretting taking a vacation from online due to being engrossed in A Canticle for Leibowitz.  Between last night and this morning,...
5 comments:
Thursday, September 24, 2015

Farewell Nabsys

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A bit over a week ago brought news that mapping instrument hopeful Nabsys had ceased operations.  As a veteran of one failed biotech, I have...
5 comments:
Thursday, September 17, 2015

How Do You Differentiate Archea and Bacteria in the First Week of High School Biology???

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I have a long standing interest in biology education -- I seriously considered it as at least a career to explore -- but now I really have s...
3 comments:
Wednesday, September 09, 2015

Freely & Unrepentantly Confessing to Heresy

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Keith Bradnam reported a huge influx of traffic for a recent post -- not surprising, since he labeled it NSFW (Not Safe For WorK).  And yes...
1 comment:
Tuesday, September 01, 2015

Ion's S5

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The Ion Torrent team rolled out a new sequencer line this morning, the S5.  The S5, whose impending release had been tipped on the internet ...
8 comments:
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Keith Robison
Dr. Robison spent 10 years at Millennium Pharmaceuticals working with various genomics & proteomics technologies & working on multiple teams attempting to apply these throughout the drug discovery process. He spent 2 years at Codon Devices working on a variety of protein & metabolic engineering projects as well as monitoring a high-throughput gene synthesis facility. After a brief bit of consulting, he rejoined the cancer drug discovery field at Infinity Pharmaceuticals in May 2009. In September 2011 he joined Warp Drive Bio, a startup applying genomics to natural product drug discovery. In February 2019 he joined Ginkgo Bioworks, a synthetic biology company. Other recurring characters in this blog are his late loyal Shih Tzu Amanda, his current Shih Poo Lily and his now adult son alias TNG (The Next Generation). Dr. Robison can be reached via his Gmail account, keith.e.robison@gmail.com You can also follow him on Twitter as @OmicsOmicsBlog.
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