Omics! Omics!

Back-of-the-envelope calculations can be quite useful, but also quite dangerous.  They are meant to be quick estimates, but can't be tak...

As others have noted , a significant theme at AGBT this year was sequencing at length.  While this year lacked true bombshells, PacBio impr...

In the previous post I described the Nabsys positional sequencer. Yesterday I got o see it running in their hotel suite here at AGBT13.

A complaint which seems to be circulating on Twitter and elsewhere is that this year’s AGBT conference on Marco Island next week doesn’t lo...

I'm committing myself this week to an uncommon intensity of posting.  It's AGBT week, and while I'm there I plan to be busy bo...

I was originally going to start this with a joke alluding to one of the signature special effects of Star Trek: The Next Generation, but giv...

As one might guess from reading this space, I always have an itch to try new sequencing technologies or updates to existing ones.  That'...

As the clear leader in the genome sequencing technology market, Illumina is often in the news.  As befitting the winter season, there's ...

This past presidential election was as nasty as any in recent memory, and so perhaps folks are reviewing their support for Churchill's d...

It's gratifying to see that yesterday's The Trouble with FASTQ item gathered a number of lively comments, and there are certainly a...

I spend a lot of time working with sequencing data, and the most common format for such data is FASTQ.  FASTQ has many things to appreciat...

Speaking of Twitter , one thing I've found it highly valuable for is discovering new tools and ideas in the bioinformatics space.  It...

For a long while, my only interaction with Twitter was to monitor key hashtags during AGBT and ASHG.  However, I've gotten myself sucked...

A confession: I've considered writing this piece for a lot of years now; not quite as many as this space has existed, but many years.  S...

It's fall, and the foliage in New England is putting on its usual spectacular show.  What isn't showing is any of the progress in na...

Roughly speaking, NGS sample preparation workflows can be split into two basic classes of workflows.  Complete molecule workflows are curren...

An email this morning alerted me that BGI Shenzhen is acquiring Complete Genomics.  I hadn't been following Complete's business very...

A news item meant to shock its readers caught my eye, but in the end I was shocked and sickened in a way that I think lay far beyond the wri...

If you tour around the extended Kendall Square area of Cambridge, you'll find a number of large construction sites.  Various projects fo...

When I was a boy, a nearly annual occurrence was a trip to Kentucky to my maternal grandparents' house.  My biological grandmother died ...