Omics! Omics!

A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discovery

Thursday, August 27, 2009

What happened to the eighth dog hair style?

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For the second time this summer Science has another step forward in understanding the genetics of dog breeds. Previously it was the identif...
Sunday, August 23, 2009

Genomes that begin with P: A follow-up

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I'm really grateful for the comments on my bit about genome assembly , two of whom (one of which is a leading author in genome assembly)...
3 comments:
Wednesday, August 19, 2009

Why do genome assemblies go bad?

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Question to ponder: given a genome assembly, how much can we ascertain as to why it didn't fully assemble. I've gotten to thinking a...
5 comments:
Monday, August 17, 2009

A Standard Set of Test Genomes

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I was away on vacation, enjoying an Internet-free existence on a tropical isle, when the brouhaha over Stephen Quake's genome sequencing...
1 comment:
Wednesday, August 05, 2009

Young Men & Fire

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60 years ago today, 15 young men floated out of a Montana sky onto rugged ground below. They were there to join another already on the scen...
Tuesday, August 04, 2009

Another Lab Cameo

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I spent a chunk of a day early last month dusting off my old lab skills. The rationale was that we were losing the senior lab tech who was ...
Thursday, July 30, 2009

Couldn't help but laugh at this ,metagenome project

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I would have thought this to be an April's Fool prank, except I came across the dataset while browsing the NCBI Short Read Archive. It ...
Tuesday, July 28, 2009

Just say no to perspective pie charts!

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> Several papers in a row tripped over one of my pet peeves. Why does anyone who cares about their data use a perspective pie chart? Pie...
5 comments:
Monday, July 27, 2009

Just what does a genome cost?

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Scientists are rarely trained in finance, and even more rarely comfortable with it. In an ideal world, experiments just happen and somehow ...
3 comments:
Wednesday, July 01, 2009

Gene Expression from A-Z

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I was playing with the data from an early RNA-Seq paper just to have a general idea of what such data looks like and to check out some favo...
Monday, June 29, 2009

Lox: The last genome for electrophoretic Sanger?

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Amongst the news last week is a bit of a surprise: the salmon genome project is choosing Sanger sequencing for the first phase of the projec...
3 comments:
Sunday, June 21, 2009

Cancer Genome Sequencing--A (Pessimistic) Interim Analysis

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The current issue of Cancer Research carries a very brief (3 pages, with one page mostly tables & figures) review of the first pulse of ...
Sunday, May 31, 2009

Teasing small insertion/deletion events from next-gen data

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My interest in next-generation sequencing is well on the way from shifting from hobby to work-central, which is exciting. So I'm now re...
2 comments:
Monday, May 25, 2009

Pondering tumor suppressors

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Now that I'm back in the cancer field full-time, I spend a lot of that time pondering the mysteries of the disease. Despite an explosio...
Tuesday, May 19, 2009

is Wolfram Alpha good for anything???

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The much heralded web tool Wolfram Alpha debuted yesterday -- and I completely forgot about it. But today a coworker asked me about it ...
3 comments:
Monday, May 11, 2009

Gene Tests Don't Blow Up!

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Today's Globe has a profile of the do-it-yourself genetic testing experiment that my former colleague Kay Aull is performing. Among th...
10 comments:
Sunday, May 03, 2009

The New Gig

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I've always been a fan of the space program and I like movies, so when a movie astronaut speaks I listen. Since Beyond Genomics changed...
Tuesday, April 21, 2009

Is Codon Optimization Bunk?

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There is a very interesting paper in Science from a week ago which hearkens back to my gene synthesis days at Codon. But first, some backgr...
8 comments:
Wednesday, April 15, 2009

Sequencing's getting so cheap...

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Here's a decidedly odd gendanken experiment which illustrates what next-gen sequencing is doing to the ocst. A common way of deriving th...
4 comments:
Sunday, April 05, 2009

Two Myeloma Patients

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TNG and i closed out the ski season a week ago. It's some great time together, but it also ends up being at times a bit of a solitary a...
1 comment:
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Keith Robison
Dr. Robison spent 10 years at Millennium Pharmaceuticals working with various genomics & proteomics technologies & working on multiple teams attempting to apply these throughout the drug discovery process. He spent 2 years at Codon Devices working on a variety of protein & metabolic engineering projects as well as monitoring a high-throughput gene synthesis facility. After a brief bit of consulting, he rejoined the cancer drug discovery field at Infinity Pharmaceuticals in May 2009. In September 2011 he joined Warp Drive Bio, a startup applying genomics to natural product drug discovery. In February 2019 he joined Ginkgo Bioworks, a synthetic biology company. Other recurring characters in this blog are his late loyal Shih Tzu Amanda, his current Shih Poo Lily and his now adult son alias TNG (The Next Generation). Dr. Robison can be reached via his Gmail account, keith.e.robison@gmail.com You can also follow him on Twitter as @OmicsOmicsBlog.
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