tag:blogger.com,1999:blog-36768584.post694256571995287632..comments2024-03-03T18:49:34.382-05:00Comments on Omics! Omics!: To Properly Assess Cancer Genomics, One Cannot Dismiss ItKeith Robisonhttp://www.blogger.com/profile/04765318239070312590noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-36768584.post-27690428906971838042016-01-27T07:48:26.151-05:002016-01-27T07:48:26.151-05:00Hi Keith,
First off, I came across your site and ...Hi Keith,<br /><br />First off, I came across your site and wanted to say thanks for providing a great cancer resource to the community. <br /><br />I thought you might find this useful infographic interesting, as it shows the detailed effects of chemotherapy in an interactive format: http://www.healthline.com/health/cancer/effects-on-body<br /><br />Naturally, I’d be delighted if you share this embeddable graphic on http://omicsomics.blogspot.com/2015/03/to-properly-assess-cancer-genomics-one.html , and/or share it on social. Either way, keep up the great work Keith!<br /><br />All the best,<br /><br />Nicole Lascurain | Assistant Marketing Manager<br />p: 415-281-3100 | e: nicole.lascurain@healthline.com<br /><br />Healthline<br />660 Third Street, San Francisco, CA 94107<br />www.healthline.com | @HealthlineNicole.lascurain@healthline.comnoreply@blogger.comtag:blogger.com,1999:blog-36768584.post-31239817233318523492015-05-01T18:45:59.588-04:002015-05-01T18:45:59.588-04:00Hi Keith, very nice summary on cancer genomics. Y...Hi Keith, very nice summary on cancer genomics. You touched immune therapy near the end, I just want to extend more. It is becoming increasingly clear that immunity against cancer are largely against neoantigens derived from somatic mutations. Cancer genome sequencing (exome and RNAseq) is essential for identification of neoantigens. There are several phase 1 clinical trials with personalized cancer vaccines. Adaptive cell transfer therapies are also starting to rely on neoantigens. So cancer genome sequencing has immediate applications in cancer immune therapiesHan Changhttps://www.blogger.com/profile/06790446366674512872noreply@blogger.comtag:blogger.com,1999:blog-36768584.post-70027873380718360102015-04-13T06:31:30.750-04:002015-04-13T06:31:30.750-04:00Beware when correcting.....
You meant papilloma vi...Beware when correcting.....<br />You meant papilloma virus....except in Burkitt's lymphoma, where the endemic African variant is associated with Epstein-Barr-Virus, which is in fact a gamma-1-Herpesvirus (Lymphocryptovirus)..... ;-)<br /><br />Apart from that, nice piece. <br />However, I do go with Jogalekar's blog (and Yevgeny Morozov) as far as the general criticism of "technological solutionism" goes. Any high throughput technology in Biology has been tempting in this regard. I know quite a lot of researchers that really don't seem to be able to come up with a good hypothesis before starting with any experiments. Just go for high-throughput and something publishable will fall off.<br /><br />Lars <br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-36768584.post-80922890090765169792015-04-02T01:38:12.996-04:002015-04-02T01:38:12.996-04:00But Burkitt lymphoma is herpesvirus related rather...But Burkitt lymphoma is herpesvirus related rather than papillomavirus related? Kienoreply@blogger.comtag:blogger.com,1999:blog-36768584.post-89634714676735721172015-04-01T22:53:38.458-04:002015-04-01T22:53:38.458-04:00"The viral work gave us the Yes oncogene and ..."The viral work gave us the Yes oncogene and later work a binding protein called YAP (Yes-associated protein). Drosophila geneticists found the receptor for YAP and named it Yorkie "<br /><br />Great piece. Just a clarification, YAP and TAZ paralogs (in mammals) are orthologous to Yorkie. Yorkie is probably best described as the effector of the Hippo pathway. It is a transcriptional co-activator that binds a slew of DNA binding proteins. The nuclear localization of Yorkie / YAP, and hence their ability to activate transcription, is regulated by the Hippo pathway.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-36768584.post-70515929874566521622015-04-01T16:27:07.311-04:002015-04-01T16:27:07.311-04:00Cliff: Thanks -- truly stupid mistake (I think I d...Cliff: Thanks -- truly stupid mistake (I think I did not have them differentiated in my mind)Keith Robisonhttps://www.blogger.com/profile/04765318239070312590noreply@blogger.comtag:blogger.com,1999:blog-36768584.post-27037765509406907362015-04-01T15:02:45.990-04:002015-04-01T15:02:45.990-04:00Thanks for this, this is very clearly written.
On...Thanks for this, this is very clearly written.<br /><br />One minor quibble, I think you meant papilloma virus instead of herpes?Cliff Beallhttps://www.blogger.com/profile/07472110231161610680noreply@blogger.comtag:blogger.com,1999:blog-36768584.post-11979815240659733992015-04-01T11:44:28.968-04:002015-04-01T11:44:28.968-04:00A reader was kind enough to point out a link for t...A reader was kind enough to point out a <a href="http://www.nature.com/news/end-of-cancer-genome-project-prompts-rethink-1.16662" rel="nofollow">link for the TCGA pause</a>, which had eluded my attempts to find it.Keith Robisonhttps://www.blogger.com/profile/04765318239070312590noreply@blogger.com