tag:blogger.com,1999:blog-36768584.post8643418256073590214..comments2024-03-03T18:49:34.382-05:00Comments on Omics! Omics!: JPM20: Illumina Launches Super Resolution InstrumentsKeith Robisonhttp://www.blogger.com/profile/04765318239070312590noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-36768584.post-16772296575103738652020-01-14T04:34:24.775-05:002020-01-14T04:34:24.775-05:00This is, in part, a testing ground for the new che...This is, in part, a testing ground for the new chemistry/SRM approach - just as the original NextSeq was for the two-colour chemistry. It took a little while for that chemistry to be optimised. Anyone who experienced v1 NextSeq data knows it wasn't good. I assume they'll work out the kinks and then incorporate it into future sequences too.<br /><br />It's also telling that although they weren't sure,t kept the NextSeq branding. NextSeq output fits well with most clinical labs. 20-120Gb is perfect for small/medium panels of scores of patients at reasonable depth. I know of several clinical labs with at least a couple of NextSeqs for this purpose. I guess they still want to focus on these labs, driving down the cost. DRAGEN also feeds in here, making analysis faster and more streamlined.<br /><br />What was slightly disappointing was the small dynamic range of flow-cells available. One of the great things about NovaSeq is the highest output is more than an order of magnitude greater then the lowest output. There's still a gap at the low end between MiSeq and NextSeq which could have been filled with a SP flow cell with, say, 50M clusters.Unknownhttps://www.blogger.com/profile/14869462307678967101noreply@blogger.com