tag:blogger.com,1999:blog-36768584.post8445453159833341969..comments2024-03-03T18:49:34.382-05:00Comments on Omics! Omics!: The Emperor of All MaladiesKeith Robisonhttp://www.blogger.com/profile/04765318239070312590noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-36768584.post-7071644306441650122013-07-05T15:45:37.436-04:002013-07-05T15:45:37.436-04:00I too screamed out a dozen times, what about this,...I too screamed out a dozen times, what about this, what about that discovery, but at 600 pages Mukherjee did an amazing job hitting all the good stuff. He could go back and write the full story but as the most complex disease, would anyone read 3,000 pages for the lay person? (As scientists we would still whine it wasn't comprehensive.) Better he left all your favorite, and my favorite, twists out of the journeyquotes shayarihttp://www.truewordings.com/noreply@blogger.comtag:blogger.com,1999:blog-36768584.post-66349648517438166012013-05-03T12:38:13.364-04:002013-05-03T12:38:13.364-04:00Mr. Mukherjee yanks you by the elbow and takes you...Mr. Mukherjee yanks you by the elbow and takes you through a roller coaster of a ride through the troughs and peaks of failures and successes in man's quest for the holy grail of medicine, the elusive cure for Cancer. Spanning almost 4000 years from the first references during the times of the Pharaohs to 2008, the epic journey covers the attempts to eradicate Cancer by the surgeons, the chemists, the radiologists and lastly the geneticists.<br /><br />Every blind alley has led to small openings, which have helped to unravel the mystery of this malignant disease and the recent successes with genetic research and early detection has helped increase the survival rates. But the battle is far from over, if one is to go by Mr. Mukherjee's passionate account.<br /><br />An excellent example of how to take medical science to the layman, I hope that this book will also inspire a large number of India's youngsters to pursue careers in research related to cancer. Harivansh Raihttp://shayari.co.in/harivansh-rai-bachchannoreply@blogger.comtag:blogger.com,1999:blog-36768584.post-75428786867904888722012-09-12T17:40:39.990-04:002012-09-12T17:40:39.990-04:00I picked up on that male breast cancer thing too. ...I picked up on that male breast cancer thing too. I am a lay reader, although inspired by my own current experience with large B cell nonHodgekins lymphoma. I know a man who survived breast cancer.Udayhttps://www.blogger.com/profile/06216463467799417926noreply@blogger.comtag:blogger.com,1999:blog-36768584.post-677927484950370612011-08-04T10:48:05.578-04:002011-08-04T10:48:05.578-04:00I too, loved this book; especially for the human/h...I too, loved this book; especially for the human/humane touch and his ability to convey a highly technical subject to laypersons. I am also glad to see (from comments) that he is open to correction. Another lapse I would cite, is there is no mention of Henrietta Lacks' name, though the use of her 'immortal' cells have added immeasurably to ALL medical research, cancer or otherwise.Aleedanoreply@blogger.comtag:blogger.com,1999:blog-36768584.post-83526996955351404342011-04-24T23:47:57.795-04:002011-04-24T23:47:57.795-04:00I would not hold the description of btz as being a...I would not hold the description of btz as being a targeted therapy against Dr. Mukherjee, the ACS does it and based on their definition it appears the NCI would as well.<br /><br /> But I'm with you, btz is in the other category as best. If btz is targeted where does that leave the taxanes ?<br /> both have characterized targets and its not surprising to me that inhibiting proteostasis would drive cells to apoptosis similar to spindle poisons.<br /><br /> But I really really liked the book, well worth reading.sandybnoreply@blogger.comtag:blogger.com,1999:blog-36768584.post-55644466255633591712011-04-16T18:14:11.909-04:002011-04-16T18:14:11.909-04:00Reading it again this weekend as a reward for gett...Reading it again this weekend as a reward for getting my taxes done. An excellent review although the blemishes might be caused by being so close to the subject. I too screamed out a dozen times, what about this, what about that discovery, but at 600 pages Mukherjee did an amazing job hitting all the good stuff. He could go back and write the full story but as the most complex disease, would anyone read 3,000 pages for the lay person? (As scientists we would still whine it wasn't comprehensive.) Better he left all your favorite, and my favorite, twists out of the journey. <br /><br />Now if DFCI could look at the Brian Druker story and learn.Paul T Morrisonhttps://www.blogger.com/profile/01812165959718025046noreply@blogger.comtag:blogger.com,1999:blog-36768584.post-2759536878938059542011-03-05T02:20:40.791-05:002011-03-05T02:20:40.791-05:00How will you feel to see a person suffering from a...How will you feel to see a person suffering from a deadly nemesis like cancer and still trying to fight and conquer his biggest enemy-cancer?<br />Well to figure this out,do read The emperor of Maladies by Siddhartha Mukherjee, who has penned it down in such a way that you feel that you are the one who is witnessing this entire journey.<br /><a href="http://www.uread.com/book/emperor-all-maladies-siddhartha-mukherjee/9780007428052" rel="nofollow"></a>uRead-bookstorehttps://www.blogger.com/profile/08871726241878548183noreply@blogger.comtag:blogger.com,1999:blog-36768584.post-53727657933623229602011-03-02T12:02:29.374-05:002011-03-02T12:02:29.374-05:00Dr. Mukherjee contacted me by email to clarify the...Dr. Mukherjee contacted me by email to clarify the Bezwoda trial -- this trial explicitly restricted recruitment to women, so the presence of a man in the trial files represents a violation of the trial design. He also mentioned that the word "obviously" has been removed from later editions. So, that critical point on my part was based largely on a misunderstanding.Keith Robisonhttps://www.blogger.com/profile/04765318239070312590noreply@blogger.comtag:blogger.com,1999:blog-36768584.post-46309009369556930022011-01-30T21:37:19.317-05:002011-01-30T21:37:19.317-05:00I am nearly done with this excellent book, and I k...I am nearly done with this excellent book, and I keep finding myself excited to see the coverage of anti-angiogenesis drugs and the story of Judah Folkman. Sad to hear I won't be hearing much. Otherwise, I agree, as a teacher of cell and molecular biology, I definitely hear many things I've learned and taught over the years!Joannehttp://www.joannelovesscience.comnoreply@blogger.comtag:blogger.com,1999:blog-36768584.post-10646697311174660612011-01-24T23:48:28.193-05:002011-01-24T23:48:28.193-05:00Loved Emperor of all Maladies.
Recently read a s...Loved Emperor of all Maladies. <br /><br />Recently read a study that found that when human cancers planted in rats developed new vasculature the cells of same were human cells not rat cells. I had thought that this new vasculature was induced by signaling from the tumor but was normal cells. The study concluded that this new vasculature was composed of cancer cells. Seems to explain why they seem poorly formed and leaky. Why would Avastin only attack the vasculature then? I would think it might attack the tumor also?robmxhttps://www.blogger.com/profile/15174540357939759383noreply@blogger.com